|Posttranslational covalent protein modifications play a key role in the regulation of many cellular processes. Enlightening the mechanisms of these modifications is therefore a significant step towards understanding cellular functioning. Structural properties and dynamic behavior of posttranslationally modified proteins give insight into modification processes. A main objective of my project is to study the characteristics of modified proteins by molecular dynamics simulations. Furthermore the effect of covalent modifications on protein complex affinity is investigated by energy analyses. Another aim of the project is the development of computational methods, that allow a accurate prediction of target sites for covalent modifications in proteins.||
Nadine Homeyer, Erlangen
"Influence of covalent protein modifications on affinity and specificity of molecular recognition processes ."
|I chose the bioinformatics group in Erlangen for my PhD, because I got interested in the projects of the group during a stay in Erlangen. I was fascinated by the possibilities computational studies offer to enlighten cellular functioning. In addition, I feel that my project will largely benefit from the program offered by the Graduate School which offers complementary expertise and training courses for the students. I believe that the knowledge and experience I will gain during my PhD in the Erlangen bioinformatics group will help me to apply computational methods to important medical problems in the future.|