Graduate School Lead Structures of Cell Function: Members: bigs_members

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	Prof. Dr. Cord-Michael Becker Lehrstuhl für Biochemie und Molekulare Medizin
Major field of interest:	Die Arbeitsgruppen des Lehrstuhls für Biochemie und Molekulare Medizin befassen sich mit den molekularen Mechanismen der interzellulären Signaltransduktion und der funktionellen Bedeutung genetischer Heterogenität.
Email:	c.-m.becker @ biochem.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Lehrstuhl Lehrstuhl für Biochemie und Molekulare Medizin Fahrstraße 17 91054 Erlangen Telefon: 09131 8524190 Telefax: 09131 8522485
Info:	http://www.biochem.uni-erlangen.de/forschung/arbeitsgruppe.php?arbeitsgruppe=1

	Prof. Dr. Thomas Dandekar Lehrstuhl für Bioinformatik
Major field of interest:	We are interested in all aspects of bioinformatics. At present their are three major interests: Analysis of cellular networks Modelling of metabolism Protein and RNA sequence and structure Study of these areas includes also statistical methods and evolutionary aspects. The aim is to understand cells, disease and biological adaptation better. Predictions are tested by well targeted experiments, often in collaborations.
Email:	dandekar @ biozentrum.uni-wuerzburg.de
Mailing address:	Universität Würzburg Lehrstuhl für Bioinformatik Am Hubland 97074 Würzburg Telefon: 0931 8884551 Telefax: 0931 8884552
Info:	http://www.biozentrum.uni-wuerzburg.de/bioinformatik

	Prof. Dr. Holger Dobbek Laboratorium für Proteinkristallographie
Major field of interest:	Metalloenzymes containing complex metal sites are able to catalyze unique reactions: they can activate and convert small molecules like H₂, CH₄, O₂ and CO/CO₂ which dominate our current discussion about renewable energy sources and the future of earth climate. allow bacteria to efficiently degrade environmental pollutants like aromatic compounds can generate radical intermediates on their substrates to facilitate unusual reaction sequences Most of these enzymes contain complex metal centers at their active sites which are usually assembled from iron and sulfur. Although a first glimpse on the structure of many of the essential metalloenzymes has been established, we have still only a poor understanding of the reactions taking place at the metal clusters. We use enzyme kinetics, spectroscopy, theoretical and crystallographic methods to learn more about natures fascinating chemistry at the interface of organic and inorganic matter.
Email:	holger.dobbek @ uni-bayreuth.de
Mailing address:	Forschungszentrum für Bio-Makromoleküle Universität Bayreuth Universitätsstr. 30 95440 Bayreuth Telefon: 0921 55-4364 Telefax: 0921 55-2432
Info:	http://www.px.uni-bayreuth.de

	Prof. Dr. Bernhard Fleckenstein Institut für Klinische und Molekulare Virologie
Major field of interest:	The activities of the Department are concentrated in a basic research program in molecular virology, with emphasis on oncogenic and human pathogenic herpesviruses and human retroviruses. In addition, they include diagnostic virology for the patients of University clinics and hospitals in Northern Bavaria. The scientific work of the project groups of the Institute of Clinical and Molecular Virology emphasises three research aspects: 1. The molecular biology and diagnostics of human pathogenic retroviruses (human immunodeficiency virus, human T cell leukemia virus), 2. the molecular analysis of viral replication and immunobiology of the human cytomegalovirus and 3. the molecular biology of DNA tumor virus.
Email:	fleckenstein @ viro.med.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Institut für Klinische und Molekulare Virologie Schloßgarten 4 91054 Erlangen Telefon: 09131 8523563 Telefax: 09131 8522101
Info:	http://www.virology.uni-erlangen.de/

	Prof. Dr. Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie
Major field of interest:	With the aim of discovering molecular probes and drug candidates for allosteric target proteins, Peter Gmeiner's group investigates design, chemical synthesis and pharmacological properties of subtype-selective GPCR ligands, TetR effectors (SFB 473) and bioactive agents for the treatment of prion-related diseases. In this context, radioligand binding studies and functional assays reveal the structural origins of subtype selectivity and intrinsic activity. Within these topics, the Gmeiner laboratory has substantial experience in the design, rganic synthesis and biological investigation of bioactive molecules and contributes to highly attractive developments in CNS-active drugs and gene therapy.
Email:	peter.gmeiner @ medchem.uni-erlangen.de
Mailing address:	Universität Erlangen Lehrstuhl für Pharmazeutische Chemie Emil-Fischer-Center Schuhstraße 19 91052 Erlangen Telefon: 09131 85-29383 Telefax: 09131 85-22585
Info:	http://www.medchem.uni-erlangen.de/gmeinerlab/

	PD. Dr. Rudolf Götz Institut für Medizinische Strahlenkunde und Zellforschung
Major field of interest:	Our work is focussed on understanding of mechanisms that regulate cell growth, cell proliferation and differentiation and prevent the intrinsic cellular death program. Dysregulation of these mechanisms causes a variety of human diseases such as cancer or neurodegenerative disorders. The Raf family of serine/threonine specific kinases (ARaf, BRaf, and CRaf) and proteins interconnected with Raf signaling play an instrumental role not only in survival and maintenance of neuronal cells but also in tissue homeostasis. Loss of BRaf, CRaf, or molecules interconnected with Raf signaling leads to cell death in various tissues and causes embryonic lethality. On the other hand, inappropriate activation of Raf, for example through point mutations, can cause cancer. Specifically, the Ras/Raf/MEK/ERK signaling pathway is deregulated in more than 30% of common cancers.
Email:	goetz @ mail.uni-wuerzburg.de
Mailing address:	Universität Würzburg Institut für Medizinische Strahlenkunde und Zellforschung Versbacher Str. 5 97078 Würzburg Telefon: 0931 20145847 Telefax: 0931 20145835
Info:	http://www.strahlenkunde.uni-wuerzburg.de/ags/goetz.htm

	Prof. Dr. Michael Hensel Institut für Klinische Mikrobiologie, Immunologie und Hygiene
Major field of interest:	The central question of research of our group is the understanding of host-pathogen interactions on the molecular level. For a complete understanding of this critical interface, we need to integrate the immune defence of the host, the response of the pathogen, the function and regulation of virulence determinants and ultimately, the manipulation of host cell function by virulence factors of pathogens.
Email:	hensel @ mikrobio.med.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Institut für Klinische Mikrobiologie, Immunologie und Hygiene Wasserturmstr. 3/5 91054 Erlangen Telefon: 09131 8523640 Telefax: 09131 8522531
Info:	http://www.klimi.med.uni-erlangen.de/AG_HENSEL/index.htm

	Prof. Dr. Wolfgang Hillen Lehrstuhl für Mikrobiologie
Major field of interest:	Tetracycline dependent gene regulation: Applications in bacteria and mammals and mechanisms of action Mechanism of carbon catabolite regulation in Gram-positive bacteria
Email:	whillen @ biologie.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Lehrstuhl für Mikrobiologie Staudtstr. 5 91058 Erlangen Telefon: 09131 8528588 Telefax: 09131 8528082
Info:	http://www.biologie.uni-erlangen.de/mibi

	Prof. Dr. Peter M. Jakob (Vertretung für Prof. Axel Haase, zurzeit Universitätspräsident) Lehrstuhl Experimentelle Physik V
Major field of interest:	Our research area is magnetic resonance imaging (MRI) and spectroscopy (MRS). Projects at our lab focus on the development of new techniques and instrumentation as well as applications on biological systems, ranging from single cells to plants, animals and humans.
Email:	peja @ physik.uni-wuerzburg.de
Mailing address:	Universität Würzburg Lehrstuhl Experimentelle Physik V Am Hubland 97074 Würzburg Telefon: 0931 8885867 Telefax: 0931 8885851
Info:	http://bio.physik.uni-wuerzburg.de/

	Prof. Dr. Jürgen Köhler Lehrstuhl für Experimentalphysik IV
Major field of interest:	The research topics cover the investigation of the electronic structure of supramolecular assemblies, molecular aggregates, polymers, and proteins.
Email:	juergen.koehler @ uni-bayreuth.de
Mailing address:	Universität Bayreuth Lehrstuhl für Experimentalphysik IV Universitätsstr. 30 95440 Bayreuth Telefon: 0921 554000 Telefax: 0921 554001
Info:	http://www.ep4.phy.uni-bayreuth.de/

	Prof. Dr. Christoph Korbmacher Lehrstuhl für Zelluläre und Molekulare Physiologie
Major field of interest:	Der aktuelle Forschungschwerpunkt unserer Arbeitsgruppe ist der epitheliale Natriumkanal (ENaC). ENaC ist der limitierende Transportschritt für die Natrium- und Flüssigkeitsresorption im distalen Nephron, im respiratorischen Epithel und im distalen Kolon. Interessanterweise führen 'gain of function'-Mutationen von ENaC zu einer hereditären Form des arteriellen Bluthochdrucks, dem Liddle-Syndrom. Diese molekulargenetischen Befunden belegen die physiologische Bedeutung dieses Kanals für die Aufrechterhaltung des Natriumhaushalts und folglich für die Langzeitkontrolle des arteriellen Blutdrucks. Von der Aufklärung der an der Regulation von ENaC beteiligten molekularen Mechanismen sind wichtige Impulse für ein besseres Verständnis der Pathogenese des arteriellen Bluthochdrucks zu erwarten.
Email:	Christoph.Korbmacher @ physiologie2.med.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Lehrstuhl für Zelluläre und Molekulare Physiologie Waldstrasse 6 91054 Erlangen Telefon: 09131 8522301 Telefax: 09131 8522770
Info:	http://www.physiologie2.uni-erlangen.de/

	Prof. Dr. Yves Muller Lehrstuhl für Biotechnik (Proteinstruktur und -design)
Major field of interest:	De novo structure determination: Classical crystallography is used to determine the crystal structures of human plasma transport proteins, growth factors, cell surface receptors and bacterial repressor molecules. Recent work includes crystal structures of rat corticoid-binding globulin and bacterial reverse tetracycline repressor variants. Probing protein architecture/protein design: Current advances in computational protein design enable the de novo design of proteins with novel properties. We have implemented established protein packing algorithms in the computer program MUMBO and are currently investigating the validity of these approaches by transforming homodimeric proteins into specific heterodimers, redesigning the specificity of enzymes and transferring ligand-binding sites between different protein scaffolds.
Email:	ymuller @ biologie.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Lehrstuhl für Biotechnik (Proteinstruktur und -design) Henkestrasse 91 91052 Erlangen Telefon: 09131 8523082 Telefax: 09131 8523080
Info:	http://www.biologie.uni-erlangen.de/biotechnik

	Dr. Gabriele Pradel Zentrum für Infektionsforschung
Major field of interest:	Pathogenicity of malaria: Molecular interactions during fertilization in the human malaria pathogen Plasmodium falciparum. The focus of our work lies in the molecular and cellular aspects of reproduction in the malaria parasite P. falciparum. It is our aim to characterize proteins that are involved in sexual stage differentiation and fertilization and that may represent promising candidates for transmission blocking strategies.
Email:	gabriele.pradel @ mail.uni-wuerzburg.de
Mailing address:	Universität Würburg Zentrum für Infektionsforschung Josef-Schneider Str. 2 / Bau D15 97080 Würburg Telefon: 0931 31-80429 Telefax: 0931 31-2578
Info:	http://www.uni-wuerzburg.de/.../zentrum_fuer_infektionsforschung/young_investigator_groups/ag_pradel/

	Prof. Dr. Ulf Rapp Institut für Medizinische Strahlenkunde und Zellforschung
Major field of interest:	Retroviruses, developmental biology Mechanisms of malignant transformation Molecular biology of oncogenes and growth factors Biochemistry of signal transduction Stem cell biology Vaccination and tumor therapy
Email:	rappur @ mail.uni-wuerzburg.de
Mailing address:	Universität Würzburg Institut für Medizinische Strahlenkunde und Zellforschung Versbacher Str. 5 97078 Würzburg Telefon: 0931 20145140 Telefax: 0931 20145835
Info:	http://www.strahlenkunde.uni-wuerzburg.de/

	Prof. Dr. Paul Rösch Department of Biopolymers
Major field of interest:	The Department of Biopolymers is engaged in many areas of research in molecular structural biology relevant to human disease and to the understanding of the basics of biological processes. Our main objective in these fields is the understanding of the relation between biopolymer structure and mechanism. We use nuclear magnetic resonance (NMR) spectroscopy, measurement of circular dichroism, fluorescence spectroscopy, and structural bioinformatics as major tools for the determination of the 3-dimensional structure, dynamic properties, and interplay of biomolecules. In addition, we perform all molecular biology work in our department, so that we are able to work on all aspects of bioengineering in our laboratories. The department has exceptionally well equipped wet labs and a full range of NMR-spectrometers: 400 MHz, 600 MHz, 700 MHz, and 800 MHz. We also participate in the NMR-facility in Munich with 750 MHz and 900 MHz instruments sponsored by the Deutsche Forschungsgemeinschaft.
Email:	Roesch @ unibt.de
Mailing address:	Dept. of Biopolymers University of Bayreuth Universitätsstr. 30, BGI 95447 Bayreuth Telefon: 0921 55-3540/1 Telefax: 0921 55-3544
Info:	http://www.unibt.de

	Prof. Dr. Thomas Scheibel Lehrstuhl fü Biomaterialien
Major field of interest:	Natürliche Materialien weisen oft optimierte Eigenschaften auf, welche die von künstlich hergestellten Produkten weit übertreffen. Dies macht unter anderem Proteine sehr attraktiv als Ideengeber für die innovative Entwicklung von neuen Materialien für einen Einsatz z.B. in der Biomedizin oder Nanobiotechnologie. Die Kernkompetenzen des Lehrstuhls für Biomaterialien liegen in der Charakterisierung von Biopolymeren, insbesondere von natürlichen Strukturproteinen, deren Modifizierung für technisch relevante Produktanforderungen, sowie die Produktion und Verarbeitung im Technikumsmaßstab.
Email:	Thomas.Scheibel @ uni-bayreuth.de
Mailing address:	Universität Bayreuth Lehrstuhl für Biomaterialien Universitätsstr. 30 Gebäude FAN/D 95447 Bayreuth Telefon: 0921 55-7360 Telefax: 0921 55-7346
Info:	http://www.neu.uni-bayreuth.de/de/Uni_Bayreuth/Fakultaeten/6_FAN/biomaterialien/de/index.html

	Prof. Dr. Ulrich Schubert Institut für Klinische und Molekulare Virologie
Major field of interest:	Function of the ubiquitin proteasome system (UPS) in presentation of newly synthesized proteins to CD8+ cytotoxic T lymphocytes (CTLs). Role(s) of the ubiquitin proteasome system (UPS) in retrovirus replication. Structure and function of regulatory virus proteins. The lentiviral protein R (Vpr). The HIV-1 p6 protein. The 11th Influenza A viruses protein, PB1-F2, that shares striking similarities to the HIV-1 Vpr regulatory protein.
Email:	schubert @ viro.med.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Institut für Klinische und Molekulare Virologie Schloßgarten 4 91054 Erlangen Telefon: 09131 8526182 Telefax: 09131 8522101
Info:	http://www.viro.med.uni-erlangen.de/

	PD. Dr. Stephan Schwarzinger Lehrstuhl Biopolymere
Major field of interest:	Mechanism and intervention in amyloid formation of the prion protein. Transient interactions in biology studied by NMR-spectroscopy: the Tat-TAR-Interaction. Protein design and assembly processes. Bio-macromolecular structure investigated by spectroscopic methods.
Email:	stephan.schwarzinger @ uni-bayreuth.de
Mailing address:	Universität Bayreuth Lehrstuhl Biopolymere Universitätsstr. 30, BGI 95447 Bayreuth Telefon: 0921 55-2046 Telefax: 0921 55-3544
Info:	http://www.bp.uni-bayreuth.de/INSTITUTE_members/Stephan_Schwarzinger/Welcome.html

	Prof. Dr. Michael Sendtner Institut für Klinische Neurobiologie
Major field of interest:	Pathogenese der spinalen Muskelatrophie: Charakterisierung von Zellkultur und Tiermodellen zur Analyse der axonalen Pathologie bei der SMA. Die Rolle neurotropher Faktoren bei der Pathogenese von Motoneuronerkrankungen: Untersuchungen an Gen-Knockout-Mäusen.
Email:	sendtner @ mail.uni-wuerzburg.de
Mailing address:	Universität Würzburg Institut für Klinische Neurobiologie Josef-Schneider-Str. 11 97080 Würzburg Telefon: 0931 201 49767 Telefax: 0931 201 49788
Info:	http://www.uni-wuerzburg.de/neurologie/abteilungen/forschung/neuroreg/

	Prof. Dr. Thomas Stamminger Institut für Klinische und Molekulare Virologie
Major field of interest:	The characterization of HCMV-encoded regulatory proteins, since they exert important functions during HCMV replication and are therefore attractive novel targets for antiviral therapy. The definition of viral effector mechanisms leading to HCMV-induced inflammatory vascular lesions. The functional investigation of protein kinases encoded by HCMV or other herpesviruses, as well as specific cellular protein kinases co-regulating viral replication. The validation of novel target genes for antiviral therapy, such as protein kinases, as well as the screening for new antivirals.
Email:	tsstammi @ viro.med.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Institut für Klinische und Molekulare Virologie Schloßgarten 4 91054 Erlangen Telefon: 09131 8526783 Telefax: 09131 8522101
Info:	http://www.viro.med.uni-erlangen.de/research/stamminger/stamminger.htm

	Prof. Dr. Clemens Steegborn Lehrstuhl für Biochemie
Major field of interest:	The topic of our work are the cellular protein complexes and mechanisms responsible for generating and transducing cellular signals. In particular, we are interested in systems involved in metabolic regulation. We use techniques from molecular biology, biochemistry, protein crystallography, and bioinformatics.
Email:	Clemens.Steegborn @ uni-bayreuth.de
Mailing address:	Universität Bayreuth Lehrstuhl BioChemie Universitätsstr. 30 95440 Bayreuth Telefon: 0921 55-2420 Telefax: 0921 55-2432
Info:	http://www.biochemie.uni-bayreuth.de/de/index.html

	Prof. Dr. Olaf Stemmann Lehrstuhl für Genetik
Major field of interest:	Chromosome mis-segregations are not only a hallmark of most cancers and promote tumor progression; when occurring during meiosis, they also result in trisomies like Down Syndrome. The aim of our research is to understand the regulations, which ensure faithful chromosome segregation in healthy cells and which might give rise to aneuploidies when malfunctioning. We are especially interested in molecular mechanisms that control the dissolution of sister chromatid cohesion in anaphase. To this end, we are conducting cell biological studies on oocytes and early embryos of frogs and on tailored transgenic lines of human cancer cells. We are combining these in vivo-experiments with in vitro-approaches that make use of the biochemically tractable system of Xenopus egg extracts.
Email:	Olaf.Stemmann @ uni-bayreuth.de
Mailing address:	Universität Bayreuth Lehrstuhl Genetik Universitätsstr. 30 /NWI 95447 Bayreuth Telefon: 0921 55-2701 Telefax: 0921 55-2710
Info:	http://www.genetik.uni-bayreuth.de/

	Prof. Dr. Heinrich Sticht Institut für Biochemie, Abteilung Bioinformatik
Major field of interest:	Principles of the regulation of tyrosine kinases and the role of viral regulator proteins. Molecular mechanisms of drug resistance of HIV-1 protease. Prediction of networks of interacting proteins using computational tools. Design of novel drugs resulting from structure-based analysis of protein aggregation.
Email:	h.sticht @ biochem.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Institut für Biochemie, Abteilung Bioinformatik Fahrstraße 17 91054 Erlangen Telefon: 09131 8524614 Telefax: 09131 8522484
Info:	http://www.biochem.uni-erlangen.de/forschung/arbeitsgruppe.php?arbeitsgruppe=6

	Prof. Dr. Matthias Ullmann Structural Biology/Bioinformatics Group
Major field of interest:	In our research, we apply physical models to understand the structure function relationship of biomolecules. Based on structura l models that were obtained by X-ray crystallography, NMR, or other methods, we investigate the thermodynamics and kinetics of biomolecu les using a large variety of theoretical methods including continuum electrostatics calculation, molecular dynamics simulations and quan tum chemical calculations.
Email:	Matthias.Ullmann @ uni-bayreuth.de
Mailing address:	Structural Biology/Bioinformatics Universität Bayreuth Universitätsstr. 30, BGI 95447 Bayreuth Telefon: 0921 55-3545 Telefax: 0921 55-3544
Info:	http://www.bisb.uni-bayreuth.de

	Prof. Dr. Michael Wegner Lehrstuhl für Biochemie und Pathobiochemie
Major field of interest:	Glial cells and neurons arise from the same pool of neuroectodermal stem cells. Whether a cell becomes a glial cell or a nerve cell is determined early in development. After the initial determination event cells continue to proliferate for some time, before they finally undergo terminal differentiation. My group is interested in the identification and characterization of transcriptional regulators that participate in determination and differentiation of neural, in particular glial cells in the developing mammalian nervous system. We currently focus on POU domain proteins, and on Sox proteins. Analysis of these transcription factors will lead to a better understanding of developmental defects, tumor formation and regenerative processes in the nervous system.
Email:	m.wegner @ biochem.uni-erlangen.de
Mailing address:	Universität Erlangen-Nürnberg Lehrstuhl für Biochemie und Pathobiochemie Fahrstraße 17 91054 Erlangen Telefon: 09131 8524620 Telefax: 09131 8522484
Info:	http://www.biochem.uni-erlangen.de/forschung/arbeitsgruppe.php?arbeitsgruppe=2

	Prof. Dr. Birgitta Wöhrl Lehrstuhl Biopolymere
Major field of interest:	Our research is based on structure-function relationships of retroviral and virus-associated enzymes and proteins with emphasis placed on the reverse transcriptase and protease of foamy viruses. Our main interest is the mechanisms involved in drug resistance and in foamy virus replication.
Email:	birgitta.woehrl @ uni-bayreuth.de
Mailing address:	Universität Bayreuth Lehrstuhl Biopolymere Universitätsstr. 30 / BGI 95440 Bayreuth Telefon: 0921 55-3542 Telefax: 0921 55-3544
Info:	http://www.bp.uni-bayreuth.de/Birgitta_Woehrl/Welcome.html

last modified 2010-12-15