|416. Novoa-Carballal, R.; Müller, A.H.E.: Synthesis of Polysaccharide-b-PEG Block Copolymers by Oxime Click, Chem. Commun. 48(31), 3781 (2012) -- DOI: 10.1039/C2CC30726J|
The oxime click reaction is shown to be a straightforward methodology for the synthesis of poly(ethylene glycol) (PEG)-polysaccharide diblock copolymers. The method is applicable to unmodified polysaccharides with a reductive end as demonstrated for dextran, hyaluronic acid and chitosan. Notably the oxime click reaction is applied for the first time to the end modification of polysaccharides.