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363. Goldmann, A.S.; Schödel, C.; Walther, A.; Yuan, J.; Loos, K.; Müller, A.H.E.: Biomimetic Mussel Adhesive Inspired Clickable Anchors Applied to the Functionalization of Fe3O4 Nanoparticles, Macromol. Rapid Commun. 31, published online on July 8 (2010) -- DOI: 10.1002/marc.201000193
Key words: click chemistry, dopamine, magnetic nanoparticles, poly(ethylene oxide)

The functionalization of magnetite (Fe3O4) nanoparticles with dopamine-derived clickable biomimetic anchors is reported. Herein, an alkyne-modified catechol-derivative is employed as the anchor, as i) the catechol-functional anchor groups possess irreversible covalent binding affinity to Fe3O4 nanoparticles, and ii) the alkyne terminus enables further functionalization of the nanoparticles by the grafting-onto approach with various possibilities offered by ‘click’ chemistry. In the present work, azido-end group functionalized Rhodamine and poly(ethylene glycol) (PEG) are utilized to coat the iron oxide nanoparticles to make them fluorescent and water soluble.

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