|380. Pfaff, A.; Shinde, V.S.; Lu, Y.; Wittemann, A.; Ballauff, M.; Müller, A.H.E.: Glycopolymer-Grafted Polystyrene Nanospheres, Macromol. Biosci. 11(2), 199 (2011) -- DOI: 10.1002/mabi.201000324|
|Key words: atom-transfer radical polymerization (ATRP), glycopolymer, gold nanoparticles, lectin recognition, spherical brushes|
The synthesis and characterization of spherical sugar-containing polymer brushes consisting of PS cores onto which chains of sugar-containing polymers have been grafted via two different techniques are described. Photopolymerization in aqueous dispersion using the functional monomer MAGlc and crosslinked or non-crosslinked PS particles covered with a thin layer of photo-initiator yielded homogeneous glycopolymer brushes attached to spherical PS cores. As an alternative, ATRP was used to graft poly-(N-acetylglucosamine) arms from crosslinked PS cores. Deprotection of the grafted brushes led to water-soluble particles that act as carriers for catalytically active gold nanoparticles. These glycopolymer chains show a high affinity to adsorb WGA whereas no binding to BSA or PNA could be detected.
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