|417. Pfaff, A.; Müller, A.H.E.: Surface Modification of Spherical Particles with Bioactive Glycopolymers, ACS Symp. Ser. 1101, 257 (2012) -- DOI: 10.1021/bk-2012-1101.ch017|
We report the generation of novel nano- and micrometer sized glycopolymer-grafted spheres, whereby controlled radical polymerization methods, namely reversible addition fragmentation chain transfer (RAFT) and atom transfer radical polymerization (ATRP), were utilized in order to synthesize glycopolymers. The interactions of these particles with various lectins were investigated to understand the effect of the specific carbohydrate that was incorporated into the polymer chain, and the architecture of the polymer chain itself. Furthermore, carbohydrate-protein interactions facilitate the cellular uptake of carbohydrate functionalized particles that might find application as cellular imaging probes.