Logo JG-Universität MainzProf. Dr. Axel Müller


DFG MU896/13: Synthesis of End-functionalized Polymers via RAFT Polymerization for Polymer-Protein Conjugates and for the Modification of Surfaces
From 04/2002 to 08/2007
Project leader: Axel H. E. Müller
Coworkers: Pierre-Eric Millard
Using RAFT polymerization, we plan to synthesize new end-functionalized polymers which can be conjugated to proteins or grafted onto pre-structured gold surfaces to form new thermo-, pH-, or salt-responsive systems. It comprises the preparation of water-soluble poly­mers, especially LCST polymers, such as poly(N-isopropyl acrylamide), a kinetic study using a new in-line FT-NIR methodology, the characterization of the polymers, the introduction of functional endgroups and the conjugation chemistry. Two different methods are to be employed: (a) RAFT polymerization in order to obtain sulfur-containing endgroups which are hydrolyzed to the corresponding thiols and can be conjugated to thiol functions of proteins or to gold surfaces; (b) Synthesis of block copoly­mers with short blocks of oligo(active ester)s for conjugation to the amino functions of proteins.

List of publications of this Project

243. Millard, P.-E.; Barner, L.; Stenzel, M.H.; Davis, T. P.; Barner- Kowollik, C.; Müller, A.H.E.: RAFT Polymerization of N-Isopropylacrylamide and Acrylic Acid under gamma-Irradiation in Aqueous Media, Macromol. Rapid Commun. 27, 821-828 (2006) -- Details
209. Schilli, C.; Zhang, M.; Müller, A.H.E.; Rizzardo, E.; Thang, S.H.; Chong, Y.K.; Edwards, K.; Karlsson, G.: A New Double-Responsive Block Copolymer Synthesized via RAFT Polymerization: , Macromolecules 37, 7861 (2004) -- Details
202. Kulkarni, S.; Schilli, C.; Müller, A.H.E.; Hoffmann, A.S.; Stayton, P.S.: Reversible Meso-Scale Smart Polymer-Protein Particles of Controlled Sizes, Bioconjugate Chemistry 15, 707 (2004) -- Details
195. Müller, A.H.E.; Walther, A.; Zhang, M.; Mori, H.: Synthesis of Highly Branched Polyelectrolytes and Silica/Polyelectrolyte Hybrids Nanoparticles, Polymeric Materials: Science & Engineering 90, 262 (2004)
194. Mori, H.; Walther, A.; André, X.; Lanzendörfer, M.; Müller, A.H.E.: Synthesis of Highly Branched Cationic Polyelectrolytes via Self-Condensing Atom Transfer Radical Copolymerization with 2-(Diethylamino)ethyl Methacrylate, Macromolecules 37, 2054 (2004) -- Details
176. Schilli, C.; Müller, A.H.E.; Rizzardo, E.; Thang, S.H.; Chong, S.: RAFT Polymers: Novel Precursors for Polymer-Protein Conjugates in: Controlled/Living Radical Polymerization, K. Matyjaszewski, Ed., ACS Symp. Ser. 854, 603 (2003) -- Details
166. Müller, A.H.E.; Schilli, C.; Lanzendörfer, M.: Kinetic and MALDI-TOF MS investigation of the RAFT polymerization of N-isopropylacrylamide, Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 43(2), 687 (2002)
163. Schilli, C.; Müller, A.H.E.; Rizzardo, E.; Thang, S.H.; Chong, S.: Controlled radical polymerization of N-isopropylacrylamide and of activated esters for the synthesis of polymer-protein and polymer-drug conjugates, Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 43(2), 126 (2002)
162. Schilli, C.; Lanzendörfer, M.; Müller, A.H.E.: Benzyl and Cumyl Dithiocarbamates as Chain Transfer Agents in the RAFT Polymerization of N-Isopropyl­acrylamide. In-Situ FT-NIR and MALDI-TOF MS Investigation, Macromolecules 35, 6819 (2002) -- Details

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