Logo JG-Universität MainzProf. Dr. Axel Müller


DFG Mu896/25: pH- and temperature induced self-organization of bis- and tris-hydrophilic polymers and hybrid particles to hydrogels (SPP 1259 "Intelligente Hydrogele")
From 10/2006 to 06/2011
Project leader: Holger Schmalz, Axel H. E. Müller
Coworkers: Alexander Schmalz, Alexander Majewski
Project within the DFG Priority Program 1259 "Intelligent Hydrogels"

We plan to synthesize polymer structures that form pH- and temperature-dependent hydrogels. To this aim we plan to combine bis- and tris-hydrophilic block co- and terpolymers of pH-sensitive polymers, e.g. poly([meth]acrylic acid) (P[M]AA) or poly(2-vinylpyridine) (P2VP), polymers with LCST behaviour, e.g. poly(N-isopropylacrylamide) (PNIPAAm) or poly(propylene oxide) (PPO), and neutral water-soluble polymers, e.g. poly(ethylene oxide) (PEO). Different combinations and topologies will lead to a multitude of structures. Triblock terpolymers, e.g. P2VP-b-PEO-b-PNIPAAm, can form different core-shell-corona micelles, which should form hydrogels on changing pH or temperature. Hydrogels based on ABCBA pentablock terpolymers with a water soluble middle block and stimuli responsive A- and B-blocks, e.g. PMAA-b-PPO-b-PEO-b-PPO-b-PMAA, are able to change their shape and size upon pH or temperature stimulus. Under conditions where only the A-block is insoluble in water a hydrogel will be formed. The size of the hydrogel (contraction/swelling) can be triggered by variations in pH or temperature, depending on the nature of the B block. Starblock copolymers with, e.g. long PAA chains in the core and a shell of PNIPAAm (or inversely, or with a PEO middle block) should be molecularly dispersed or form a hydrogel, depending on pH and temperature. Here, the junction points are formed by collapsed PNIPAAm or PAA and the hydrophilic chains can expand more or less. In the center of such a star we could pose silica, silsesquioxane or magnetic nanoparticles, leading to hybrid- or ferro-hydrogels with a defined array of the inorganic particles.
Homepage: http://spp-hydrogele.bci.uni-dortmund.de/

List of publications of this Project

347. Schmalz, A.; Hanisch, M.; Schmalz, H.; Müller, A.H.E.: Double stimuli-responsive behavior of linear and star-shaped poly(N,N-diethylaminoethyl methacrylate) in aqueous solution, Polymer 51(6), 1213 (2010) -- DOI: 10.1016/j.polymer.2009.11.023 -- Details
343. Schacher, F.H.; Reinicke, S.; Walther, A.; Schmalz, H.; Müller, A.H.E.: New amphiphilic nanostructures based on block terpolymers made by anionic polymerization in: New Smart Materials via Metal Mediated Macromolecular Engineering, E. Khosravi, Y. Yagci, Y. Savelyev, Eds., NATO Science for Peace and Security Series, Springer, Dordrecht, p. 167-186, ISBN 978-90-481-3276-8 (2009) -- Details
315. Schacher, F.H.; Müllner, M.; Schmalz, H.; Müller, A.H.E.: New Block Copolymers with Poly(N,N-dimethylaminoethyl methacrylate) as a Double Stimuli-Responsive Block, Macromol. Chem. Phys. 210, 256 (2009) -- DOI: 10.1002/macp.200800557 -- PDF -- Details
287. Müller, A.H.E.; Plamper, F.A.; Schmalz, A.; Ballauff, M.: Tuning the thermoresponsiveness of weak polyelectrolytes by pH and light: lower and upper critical solution temperature of poly(N,N-dimethylaminoethyl methacrylate), Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 49(1), 1099 (2008)
275. Plamper, F.A.; Schmalz, A.; Ballauff, M.; Müller, A.H.E.: Tuning the Thermoresponsiveness of Weak Polyelectrolytes by pH and Light: Lower and Upper Critical Solution Temperature of Poly(N,N-dimethylaminoethyl methacrylate), J. Am. Chem. Soc. 129, 14538 (2007)
274. Plamper, F.A.; Ruppel, M.; Schmalz, A.; Borisov, O.V.; Ballauff, M.; Müller, A.H.E.: Tuning the Thermoresponsive Properties of Weak Polyelectrolytes: Aqueous Solutions of Star-Shaped and Linear Poly(N,N-dimethylaminoethyl methacrylate), Macromolecules 40, 8361 (2007) -- Details
270. Ah Toy, A..; Reinicke, S.; Müller, A.H.E.; Schmalz, H.: One-pot synthesis of polyglycidol containing block copolymers with alkyllithium initiators using the phosphazene base t-BuP4 , Macromolecules 40, 5241 (2007)

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